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Chicago Cubs vs Pittsburgh Pirates MLB Picks & Prediction 7/25: Pirates Favored on Moneyline

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Published by João Bitencourte

July 25, 2026

Updated 77 days ago

Our Verdict

  • Pick : Pittsburgh Pirates -132
  • Confidence : Medium

SATURDAY, JULY 25

6:40 PM

Venue & Date

The Pirates host the Cubs at PNC Park on July 25. First pitch set for 6:40 PM ET.

Team Records

Cubs are 55-43 overall, 27-23 on the road. Pirates are 51-48 overall, 27-24 at home.

Run Production

Pirates average 5.27 runs per game with a .261 team batting average. Cubs score 5.10 per game with a .245 avg.

Moneyline Odds

Pittsburgh Pirates are favored at -132 on the moneyline over the Chicago Cubs.

Game Over!

BONUS PICKS - SAME GAME

Additional betting opportunities for Pittsburgh Pirates vs Chicago Cubs
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Pirates Moneyline

Pittsburgh Pirates -132

High Confidence

Pirates on the moneyline offer best value, given slight home edge and scoring efficiency. Medium-sized favorite, but worth the price at -132.

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Pirates Run Line

Pittsburgh Pirates -1.5 (+168)

Medium Confidence

If you want higher payout, play Pirates -1.5 at +168. Their offense backs the spread: 5.27 runs per game leads head-to-head.

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Game Total OVER

Over 8 (-108)

Low Confidence

Both teams average over 5 runs per game. Pirates are 34-17 to the OVER at home, supporting a look at Over 8 runs.

João Bitencourte
Pre-game analysis

By João Bitencourte, Handicapper

July 25, 2026

Updated 77 days ago

Chicago Cubs at Pittsburgh Pirates: Game Preview

Five of the last ten Pirates games at home have surpassed the posted total, driven by MLB’s most consistent home OVER trend. This matchup with the Cubs brings two evenly-matched teams, but home-field and statistical edges tilt the prediction.

The Pirates enter 51-48 overall and 27-24 at PNC Park. The Cubs are 55-43 overall but just 27-23 on the road. While Chicago’s record appears stronger, Pittsburgh’s home production is the deciding category. Run production and strong performance at the plate fuel the Pirates’ position as a modest favorite at -132 on the moneyline.

Data-Driven Analysis

Key StatChicago CubsPittsburgh Pirates
Overall Record55-4351-48
Road/Home Record27-23 (Away)27-24 (Home)
Batting Avg.245.261
Runs Per Game5.105.27
Team OPS.751.763
Pitching ERA4.274.26
Home/Away OVER Trend26-24 (O/U away)34-17 (O/U home)

Pirates hit .261 as a team and score 5.27 per game, topping the Cubs in both categories. Their home O/U trends and offensive consistency are where I find the real betting edge.

Key Injury Reports

Chicago Cubs: Porter Hodge, Cade Horton, Matt Shaw, Daniel Palencia, Ben Brown, Riley Martin, Ethan Roberts

Pittsburgh Pirates: Oneil Cruz, Chris Devenski, Hoby Milner, Evan Sisk, Endy Rodriguez, Konnor Griffin, Phil Maton, Trent Thornton, Rafael Flores Jr.

Key Matchups

Matchup 1: Pirates Offense vs Cubs Pitching

Pittsburgh averages 5.27 runs, hitting for more average and power than Chicago. The Cubs allow 4.46 runs per game, but their pitching staff has given up 157 home runs in 102 games, a concern against Pittsburgh’s deep lineup.

Matchup 2: Cubs on the Road vs Pirates at Home

The Cubs are a mediocre 27-23 away from Wrigley, only .540 winning percentage. The Pirates are 27-24 at PNC, but pair that with their strong home OVER trends—offense typically rises at home, providing a real advantage both outright and on the run line.

Matchup 3: Team Plate Discipline

The Cubs have drawn 448 walks, leading to a .338 OBP. Pittsburgh, however, matches with 382 walks—lower, but their higher batting average closes the gap. Both teams have standout discipline, but Pittsburgh has the more consistent team approach.

Summary

  • Consensus Line: Pittsburgh Pirates -132 (Moneyline)
  • Data-Driven Prediction: Pirates win straight up at home
  • Confidence: Medium
  • Reasoning: I see enough statistical edge and better scoring at home for the Pirates to balance out the Cubs’ overall record. Back the home side on the moneyline at -132.

21+ only. Gambling problem? Call 1-800-GAMBLER. For entertainment purposes only.

João Bitencourte

João Bitencourte

Handicapper

5+ Years Experience

João AKA “jaosouthside” is handicapper with a background few in the industry can claim. He began his career as an broker for major European betting syndicates, where his role was to monitor global odds and execute high-volume trades across both sharp and soft sportsbooks.

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