49ers vs Seahawks odds - NFL Week 15

49ers vs Seahawks betting preview for NFL Week 15. The San Francisco 49ers are small favorites out on the road against Seattle.

The San Francisco 49ers, a surging team but one with some important injuries, will face the Seattle Seahawks on Thursday, December 15th, 2022. The Seahawks, who have been crashing in the standings over the last few weeks, will host the game (start time of 5:15 PM PT). The 49ers enter the game as small road favorites, set at -3.5 (bet365). In a tough game to call, bettors should be going with the underdog Seahawks.

The Pick: Seattle to win at +155 (about 3/2) (bet365)

The San Francisco 49ers will enter the game with a record of 9-4 on the season. This is a team that has won six straight after opening the season with a 3-4 record. They look like a dunk to beat a reeling Seattle team, however, the 49ers have some injuries. Furthermore, San Fran's winning streak could be criticized.

The 49ers have not played in another team's building since October 30th when San Francisco beat the Rams. They won a neutral-site game against Arizona since then but otherwise, the 49ers have played comfortably as hosts. They are going on the road in Week 15 and that could change their direction, especially since they don't have an experienced quarterback.

Deebo Samuel is out, Brock Purdy is questionable

San Francisco will be missing Deebo Samuel for what could be a few weeks according to David Lombardi of The Athletic. In old news, the 49ers are missing their top quarterbacks and it's not clear if Brock Purdy is capable of leading the team or if he just had a good game in Week 14. On that matter, Purdy is actually questionable for Week 15. Christian McCaffrey is also questionable and the 49ers may not resemble the team that won six straight in their Week 15 game.

Will the quarterback that San Francisco sends out be able to handle a hostile environment? If it's Purdy, let's not forget that he was playing at home when he had his outburst last week. Things could change for 'cisco as they go on the road, noting that the 49ers are just 3-3 as a road team this season with losses to Chicago, Denver, and Atlanta.

Seahawks are at a do-or-die point in their season

Meanwhile, the Seattle Seahawks are 7-6 on the season. They have lost three of four in recent weeks with only a four-point spread over the LA Rams helping Seattle's cause. They don't have an easy schedule coming up and Seattle's bubble may be bursting.

However, there's plenty of reason to be critical of San Francisco's chances in this game. The right move for bettors is to let the odds do the talking in this one. The Seahawks are out at +155 (about 3/2) on the moneyline. That's a good line to take with the attitude that you either lose small or win at pretty good odds.

49ers vs Seahawks betting recommendation

  • Seahawks to win at +155 (3/2) with bet365

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